Chang, Ee; Schwartz, Brett; Draffan, Alistair; Banwell, Martin; Willis, Anthony
The natural product (-)-platencin is a potent antibacterial agent that exerts its effects through a novel mode of action. As such, it is an important lead in the development of next-generation antibacterials that are urgently needed because of the rapidly developing resistance to current therapies. The work reported here concerns the development of a convergent and chemoenzymatic total synthesis of (-)-platencin by methods that should provide access to a range of biologically relevant...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.