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A chemoenzymatic and fully stereocontrolled total synthesis of the antibacterial natural product (-)-platencin

Chang, Ee; Schwartz, Brett; Draffan, Alistair; Banwell, Martin; Willis, Anthony

Description

The natural product (-)-platencin is a potent antibacterial agent that exerts its effects through a novel mode of action. As such, it is an important lead in the development of next-generation antibacterials that are urgently needed because of the rapidly developing resistance to current therapies. The work reported here concerns the development of a convergent and chemoenzymatic total synthesis of (-)-platencin by methods that should provide access to a range of biologically relevant...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/64018
Source: Chemistry - An Asian Journal
DOI: 10.1002/asia.201403069

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