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Neurite infiltration and cellular response to electrospun polycaprolactone scaffolds implanted into the brain

Nisbet, David; Rodda, AE; Horne, Malcolm K.; Forsythe, John S.; Finkelstein, D I


Assessment of axonal infiltration and guidance within neural tissue engineering scaffolds, along with the characterisation of the inflammatory response, is critical in determining these scaffolds' potential for facilitating neural repair. In this study, the extent of microglial and astrocytic response was measured following implantation of electrospun poly(ε-caprolactone) (PCL) scaffolds into the caudate putamen of the adult rat brain. The inflammation peaked at around 4 days (microglia) and 7...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biomaterials
DOI: 10.1016/j.biomaterials.2009.05.011


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