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Intrinsic disorder mediates cooperative signal transduction in STIM1

Furukawa, Yukio; Teraguchi, Shunsuke; Ikegami, Takahisa; Dagliyan, Onur; Jin, Lin; Hall, Damien; Dokholyan, Nikolay V.; Namba, Keiichi; Akira, Shizuo; Kurosaki, Tomohiro; Baba, Yoshihiro; Standley, Daron M.


Intrinsically disordered domains have been reported to play important roles in signal transduction networks by introducing cooperativity into protein-protein interactions. Unlike intrinsically disordered domains that become ordered upon binding, the EF-SAM domain in the stromal interaction molecule (STIM) 1 is distinct in that it is ordered in the monomeric state and partially unfolded in its oligomeric state, with the population of the two states depending on the local Ca2 + concentration. The...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2014.03.006


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