Intrinsic disorder mediates cooperative signal transduction in STIM1
Furukawa, Yukio; Teraguchi, Shunsuke; Ikegami, Takahisa; Dagliyan, Onur; Jin, Lin; Hall, Damien; Dokholyan, Nikolay V.; Namba, Keiichi; Akira, Shizuo; Kurosaki, Tomohiro; Baba, Yoshihiro; Standley, Daron M.
Intrinsically disordered domains have been reported to play important roles in signal transduction networks by introducing cooperativity into protein-protein interactions. Unlike intrinsically disordered domains that become ordered upon binding, the EF-SAM domain in the stromal interaction molecule (STIM) 1 is distinct in that it is ordered in the monomeric state and partially unfolded in its oligomeric state, with the population of the two states depending on the local Ca2 + concentration. The...[Show more]
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|Source:||Journal of Molecular Biology|
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