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IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Batten, Marcel L; Ramamoorthi, Nandhini; Kljavin, Noelyn M; Ma, Cindy; Cox, Jennifer H; Dengler, Hart S; Danilenko, Dimitry M; Caplazi, Patrick; Wong, Melanie; Fulcher, David; Cook, Matthew; King, Cecile; Tangye, Stuart; de Sauvage, Frederic J; Ghilardi, Nico; Ma, Cindy

Description

Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on support from T follicular helper (TFH) cells. TFH cells are characterized by their localization to the B cell follicle and their high expression of the costimulatory molecules ICOS and PD1 and the cytokine IL-21, which promotes immunoglobulin (Ig) class switching and production by B cells. We show that the heterodimeric cytokine IL-27 is critical for the function of TFH cells and for normal and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/63111
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20100064

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