IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
Batten, Marcel L; Ramamoorthi, Nandhini; Kljavin, Noelyn M; Ma, Cindy; Cox, Jennifer H; Dengler, Hart S; Danilenko, Dimitry M; Caplazi, Patrick; Wong, Melanie; Fulcher, David; Cook, Matthew; King, Cecile; Tangye, Stuart; de Sauvage, Frederic J; Ghilardi, Nico; Ma, Cindy
Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on support from T follicular helper (TFH) cells. TFH cells are characterized by their localization to the B cell follicle and their high expression of the costimulatory molecules ICOS and PD1 and the cytokine IL-21, which promotes immunoglobulin (Ig) class switching and production by B cells. We show that the heterodimeric cytokine IL-27 is critical for the function of TFH cells and for normal and...[Show more]
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|Source:||Journal of Experimental Medicine|
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