Yuan, Ling; Hu, Jie; Luo, Yan; Liu, QingYun; Li, Tao; Parish, Christopher; Freeman, Craig; Zhu , XiaoBo; Ma, Wei; Hu , XuTing; Yu , HongHua; Tang , Shibo
Purpose: The objectives of this study were to determine whether high-glucose-induced upregulation of heparanase (HPSE) expression and differential heparanase expression in human retinal vascular endothelial cells (HRECs) can alter HREC migration and proliferation. We also aimed to determine whether HREC migration and proliferation correlate with the levels of protein kinase B (Akt) and extracellular-signal-regulated kinase (ERK) phosphorylation and activation. Methods: HRECs were treated with...[Show more]
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