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Upregulation of heparanase in high-glucose-treated endothelial cells promotes endothelial cell migration and proliferation and correlates with Akt and extracellular-signal-regulated kinase phosphorylation

Yuan, Ling; Hu, Jie; Luo, Yan; Liu, QingYun; Li, Tao; Freeman, Craig; Zhu, XiaoBo; Ma, Wei; Hu, XuTing; Yu, HongHua; Tang, Shibo; Parish, Christopher


Purpose: The objectives of this study were to determine whether high-glucose-induced upregulation of heparanase (HPSE) expression and differential heparanase expression in human retinal vascular endothelial cells (HRECs) can alter HREC migration and proliferation. We also aimed to determine whether HREC migration and proliferation correlate with the levels of protein kinase B (Akt) and extracellular-signal-regulated kinase (ERK) phosphorylation and activation. Methods: HRECs were treated with...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Molecular Vision
Access Rights: Open Access


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