Formate production through biocatalysis
Date
2013
Authors
Alissandratos, Lee
Kim, Hye-Kyung
Easton, Christopher
Journal Title
Journal ISSN
Volume Title
Publisher
Landes Bioscience
Abstract
The generation of formate from CO2 provides a method for sequestration of this greenhouse gas as well as the production of a valuable commodity chemical and stabilized form of hydrogen fuel. Formate dehydrogenases are enzymes with the potential to catalyze this reaction; however they generally favor the reverse process, i.e., formate oxidation. By contrast, the formate dehydrogenase of the acetogen Clostridium carboxidivorans has been found to preferentially catalyze the reduction of CO2. This is in accord with its natural role to introduce CO2 as a carbon source in the Wood-Ljungdahl pathway. The direction of catalysis derives from the enzyme's low affinity for formate. This enzyme is therefore an excellent candidate for biotechnological applications aimed at producing formic acid and derivative chemicals from CO2.
Description
Keywords
Keywords: bacterial protein; carbon dioxide; formate dehydrogenase; formic acid; formic acid derivative; acetogens; article; biocatalysis; carbon cycle; Clostridium; Clostridium carboxidivorans; CO2 fixation; CO2 reduction; enzymology; genetics; Hydrogen storage; k
Citation
Collections
Source
Bioengineered
Type
Journal article
Book Title
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2037-12-31