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Silencing of essential genes by RNA interference in Haemonchus contortus

Zawadzki, Jody L; Kotze, Andrew; Fritz, Julie-Anne; Johnson, Nick; Hemsworth, J E; Hines, B.M.; Behm, Carolyn


In this study we assessed three technologies for silencing gene expression by RNA interference (RNAi) in the sheep parasitic nematode Haemonchus contortus. We chose as targets five genes that are essential in Caenorhabditis elegans (mitr-1, pat-12, vha-19, glf-1 and noah-1), orthologues of which are present and expressed in H. contortus, plus four genes previously tested by RNAi in H. contortus (ubiquitin, tubulin, paramyosin, tropomyosin). To introduce double-stranded RNA (dsRNA) into the...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Parasitology
DOI: 10.1017/S0031182012000121


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