Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking
We have determined the three-dimensional structure of the protein complex between latexin and carboxypeptidase A using a combination of chemical cross-linking, mass spectrometry and molecular docking. The locations of three intermolecular cross-links were identified using mass spectrometry and these constraints were used in combination with a speed-optimised docking algorithm allowing us to evaluate more than 3 × 1011 possible conformations. While cross-links represent only limited structural...[Show more]
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|Source:||Protein Engineering Design and Selection|
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