Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides
Date
2012
Authors
Ambrus, Joseph
Halliday, Jill
Kanizaj, Nicholas
Absalom, Nathan
Harpsoe, Kaspar
Balle, Thomas
Chebib, Mary
McLeod, Malcolm
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).
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Keywords
Keywords: bungarotoxin receptor; cysteine; maleimide; methyllycaconitine; nicotinic receptor blocking agent; article; controlled study; covalent bond; mutant; proton nuclear magnetic resonance; substitution reaction; synthesis; Animals; Maleimides; Models, Biologic
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Source
Chemical Communications
Type
Journal article
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2037-12-31
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