ATG16L1T300A shows strong associations with disease subgroups in a large Ausralian IBD populaton: further support for significant disease heterogeneity
Fowler, Elizabeth V; Doecke, James; Simms, Lisa A; Zhao, Zhen; Webb, Penelope M; Hayward, Nicholas K; Whiteman, David C; Florin, Timothy H.J.; Montgomery, Grant W; Cavanaugh, Juleen; Radford-Smith, Graham
OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of inflammatory bowel disease (IBD), representing a significant health-care burden. A variant in the autophagy gene ATG16L1 (T300A) has been newly identified as a CD susceptibility locus by genome-wide association. Our aim was to assess the contribution of T300A in determining disease susceptibility and phenotype in two independent Australian IBD cohorts and explore the relationship between T300A and...[Show more]
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|Source:||American Journal of Gastroenterology|
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