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ATG16L1T300A shows strong associations with disease subgroups in a large Ausralian IBD populaton: further support for significant disease heterogeneity

Fowler, Elizabeth V; Doecke, James; Simms, Lisa A; Zhao, Zhen; Webb, Penelope M; Hayward, Nicholas K; Whiteman, David C; Florin, Timothy H.J.; Montgomery, Grant W; Cavanaugh, Juleen; Radford-Smith, Graham

Description

OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of inflammatory bowel disease (IBD), representing a significant health-care burden. A variant in the autophagy gene ATG16L1 (T300A) has been newly identified as a CD susceptibility locus by genome-wide association. Our aim was to assess the contribution of T300A in determining disease susceptibility and phenotype in two independent Australian IBD cohorts and explore the relationship between T300A and...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/61235
Source: American Journal of Gastroenterology
DOI: 10.1111/j.1572-0241.2008.02023.x

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