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Thiol-ene reaction: a versatile tool in site-specific labelling of proteins with chemically inert tags for paramagnetic NMR

Li, Qing-Feng; Yang, Yin; Maleckis, Ansis; Otting, Gottfried; Su, Xun-Cheng

Description

Site-specific tagging of proteins with paramagnetic lanthanides generates valuable long-range structure restraints for structural biology by NMR spectroscopy. We show that the thiol-ene addition reaction offers a powerful tool for tagging proteins in a chemically stable manner with very small lanthanide tags. This journal is

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/60820
Source: Chemical Communications
DOI: 10.1039/c2cc17900h

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