Characterization, chromosomal location and genomic neighborhood of a ratite ortholog of a gene with gonadal expression in mammals
Date
2008
Authors
Janes, Daniel E
Ezaz, Tariq
Graves, Jennifer
Edwards, Scott V
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
Abstract
A locus that we name SubA was discovered during large-scale sequencing and characterization of a bacterial artificial chromosome library from an emu, Dromaius novaehollandiae. This locus yields a significantly negative Tajimas D in emus and is conserved across emu, chicken, mouse, and human. Expression of SubA orthologs has been reported in human ovaries and in mouse testes, but remains unknown in emus. The locus was physically mapped onto a pair of microchromosomes in emus by fluorescent in situ hybridization and also in chicken as previously reported. By characterizing emu SubA in this article, we aim to improve current descriptions of the cascade of genes associated with avian sex differentiation. Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles.
Description
Keywords
Keywords: Aves; Bacteria (microorganisms); Dromaiidae; Dromaius novaehollandiae; Mammalia; Palaeognathae; Reptilia
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Source
Integrative and Comparative Biology
Type
Journal article