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Bacterial degradation of strobilurin fungicides: a role for a promiscuous methyl esterase activity of the subtilisin proteases?

Clinton, Brook; Warden, Andrew C; Haboury, Stephanie; Easton, Christopher; Kotsonis, Steven; Taylor, Matthew C; Oakeshott , John; Russell, Robyn J; Scott, Colin


Strobilurin fungicides are some of the most heavily used antifungal chemicals in agriculture. However, little is known of their fate in the environment. We have identified bacteria that slowly transform strobilurin fungicides via hydrolysis of a methyl ester group in the toxophore, rendering them non-fungicidal. A carboxypeptidase (subtilisin Carlsberg) was found to have this activity, albeit with low specific activity (2.4 × 10-2 nmol s-1 mg-1), and to possess specificity towards an analog of...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Biocatalysis and Biotransformation
DOI: 10.3109/10242422.2011.578740


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