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Binding inhibitors of the bacterial sliding clamp by design

Wijffels, Gene; Johnson, Wynona M; Oakley, Aaron; Turner, Kathleen; Epa, V Chandana; Briscoe, Susan J; Polley, Mitchell; Liepa, Andris J; Hofmann, Albert; Buchardt, Jens; Christensen, Caspar; Prosselkov, Pavel; Dalrymple, Brian Paul; Alewood, Paul F; Jennings, Phil A; Dixon, Nicholas; Winkler, David A

Description

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma

dc.contributor.authorWijffels, Gene
dc.contributor.authorJohnson, Wynona M
dc.contributor.authorOakley, Aaron
dc.contributor.authorTurner, Kathleen
dc.contributor.authorEpa, V Chandana
dc.contributor.authorBriscoe, Susan J
dc.contributor.authorPolley, Mitchell
dc.contributor.authorLiepa, Andris J
dc.contributor.authorHofmann, Albert
dc.contributor.authorBuchardt, Jens
dc.contributor.authorChristensen, Caspar
dc.contributor.authorProsselkov, Pavel
dc.contributor.authorDalrymple, Brian Paul
dc.contributor.authorAlewood, Paul F
dc.contributor.authorJennings, Phil A
dc.contributor.authorDixon, Nicholas
dc.contributor.authorWinkler, David A
dc.date.accessioned2015-12-10T22:53:15Z
dc.identifier.issn0022-2623
dc.identifier.urihttp://hdl.handle.net/1885/59270
dc.description.abstractThe bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma
dc.publisherAmerican Chemical Society
dc.sourceJournal of Medicinal Chemistry
dc.subjectKeywords: bacterial DNA; bacterial sliding clamp; biphenyl; biphenyl oxime; replisome; unclassified drug; article; binding affinity; binding site; carboxy terminal sequence; crystal structure; DNA binding motif; DNA repair; DNA replication; pharmacophore; protein m
dc.titleBinding inhibitors of the bacterial sliding clamp by design
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume54
dc.date.issued2011
local.identifier.absfor030406 - Proteins and Peptides
local.identifier.ariespublicationu4005981xPUB482
local.type.statusPublished Version
local.contributor.affiliationWijffels, Gene, CSIRO Livestock
local.contributor.affiliationJohnson, Wynona M, CSIRO Materials Science and Engineering
local.contributor.affiliationOakley, Aaron, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationTurner, Kathleen, CSIRO Materials Science and Engineering
local.contributor.affiliationEpa, V Chandana, CSIRO Materials Science and Engineering
local.contributor.affiliationBriscoe, Susan J, CSIRO Livestock Industries
local.contributor.affiliationPolley, Mitchell, CSIRO Materials Science and Engineering
local.contributor.affiliationLiepa, Andris J, CSIRO Materials Science and Engineering
local.contributor.affiliationHofmann, Albert, CSIRO Materials Science and Engineering
local.contributor.affiliationBuchardt, Jens, University of Queensland
local.contributor.affiliationChristensen, Caspar, University of Queensland
local.contributor.affiliationProsselkov, Pavel, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDalrymple, Brian Paul, CSIRO
local.contributor.affiliationAlewood, Paul F, University of Queensland
local.contributor.affiliationJennings, Phil A, CSIRO Livestock
local.contributor.affiliationDixon, Nicholas, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWinkler, David A, CSIRO Materials Science and Engineering
local.description.embargo2037-12-31
local.bibliographicCitation.issue13
local.bibliographicCitation.startpage4831
local.bibliographicCitation.lastpage4838
local.identifier.doi10.1021/jm2004333
local.identifier.absseo970103 - Expanding Knowledge in the Chemical Sciences
dc.date.updated2016-02-24T10:24:24Z
local.identifier.scopusID2-s2.0-79960180851
CollectionsANU Research Publications

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