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Binding inhibitors of the bacterial sliding clamp by design

Wijffels, Gene; Johnson, Wynona M; Oakley, Aaron; Turner, Kathleen; Epa, V Chandana; Briscoe, Susan J; Polley, Mitchell; Liepa, Andris J; Hofmann, Albert; Buchardt, Jens; Christensen, Caspar; Prosselkov, Pavel; Dalrymple, Brian Paul; Alewood, Paul F; Jennings, Phil A; Dixon, Nicholas; Winkler, David A

Description

The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/59270
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm2004333

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