Binding inhibitors of the bacterial sliding clamp by design
Date
2011
Authors
Wijffels, Gene
Johnson, Wynona M
Oakley, Aaron
Turner, Kathleen
Epa, V Chandana
Briscoe, Susan J
Polley, Mitchell
Liepa, Andris J
Hofmann, Albert
Buchardt, Jens
Journal Title
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Volume Title
Publisher
American Chemical Society
Abstract
The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisoma
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Keywords
Keywords: bacterial DNA; bacterial sliding clamp; biphenyl; biphenyl oxime; replisome; unclassified drug; article; binding affinity; binding site; carboxy terminal sequence; crystal structure; DNA binding motif; DNA repair; DNA replication; pharmacophore; protein m
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Source
Journal of Medicinal Chemistry
Type
Journal article
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Restricted until
2037-12-31
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