Rapid and Enantioselective Assembly of the Lycorine Framework Using Chemoenzymatic Techniques
Date
2009
Authors
Jones, Matthew
Schwartz, Brett
Willis, Anthony
Banwell, Martin
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Volume Title
Publisher
American Chemical Society
Abstract
The pentacyclic framework associated with the alkaloid (-)-lycorine (1) can be assembled in as few as six steps from the enantiomerically pure cis-1,2-dihydrocatechol 3 which is itself readily available on a large scale through the whole-cell biotransformation of bromobenzene. The methodology has been used in developing the first synthesis of compound 2, a derivative of lycorine.
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Keywords
Keywords: Amaryllidaceae alkaloid; bromobenzene; enzyme; lycorine; nitrobenzoic acid derivative; phenanthridine derivative; article; chemistry; metabolism; synthesis; X ray crystallography; Amaryllidaceae Alkaloids; Bromobenzenes; Crystallography, X-Ray; Enzymes; N
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Source
Organic Letters
Type
Journal article
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2037-12-31
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