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Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases

Zhou, Huina; Brock, Joseph; Liu, Dan; Board, Philip; Oakley, Aaron

Description

The reduction of dehydroascorbate (DHA) to ascorbic acid (AA) is a vital cellular function. The omega-class glutathione transferases (GSTs) catalyze several reductive reactions in cellular biochemistry, including DHA reduction. In humans, two isozymes (GSTO1-1 and GSTO2-2) with significant DHA reductase (DHAR) activity are found, sharing 64% sequence identity. While the activity of GSTO2-2 is higher, it is significantly more unstable in vitro. We report the first crystal structures of human...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/54590
Source: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2012.04.014

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