Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
Date
2011
Authors
Sun, Ramon
Board, Philip
Blackburn, Anneke
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Volume Title
Publisher
American Association for Cancer Research
Abstract
Background: Cancer cells have a different metabolic profile compared to normal cells. The Warburg effect (increased aerobic glycolysis) and glutaminolysis (increased mitochondrial activity from glutamine catabolism) are well known hallmarks of cancer and
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Keywords
Keywords: adenosine triphosphate; arsenic trioxide; cytochrome c oxidase; dichloroacetic acid; hypoxia inducible factor 1alpha; Myc protein; proton transporting adenosine triphosphatase; reactive oxygen metabolite; adenosine triphosphate; antineoplastic agent; arse Arsenic trioxide; Breast cancer; Dichloroacetate; Electron transport chain; Mitochondria
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Source
Molecular Cancer Therapeutics
Type
Journal article
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Restricted until
2037-12-31
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