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Methods to analyze microRNA-mediated control of mRNA translation

Clancy, Jennifer; Nousch, Marco; Humphreys, David T; Westman, Belinda J; Beilharz, TH; Preiss, Thomas


MicroRNAs (miRs) are an important class of gene regulators that affect a wide range of biological processes. Despite the early recognition of miRs as translational regulators and intense interest in studying this phenomenon, it has so far not been possible to derive a consensus model for the underlying molecular mechanism(s). The potential of miRs to act in a combinatorial manner and to also promote mRNA decay creates conceptual and technical challenges in their study. Here, we discuss critical...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Methods in Enzymology
DOI: 10.1016/S0076-6879(07)31006-9


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