Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses
Bhatt, Tarun; Khan, Sameena; Dwivedi, Ved; Banday, Mudassir; Sharma, Arvind; Chandele, Anmol; Camacho, Noelia; de Pouplana, Lluis Ribas; Wu, Yang; Craig, Alister G; Mikkonen, Antti; Maier, Alex; Yogavel, Manickam; Sharma, Amit
Malaria infection triggers pro-inflammatory responses in humans that are detrimental to host health. Parasite-induced enhancement in cytokine levels correlate with malaria-associated pathologies. Here we show that parasite tyrosyl-tRNA synthetase (PfTyrRS), a housekeeping protein translation enzyme, induces pro-inflammatory responses from host immune cells. PfTyrRS exits from the parasite cytoplasm into the infected red blood cell (iRBC) cytoplasm, from where it is released into the...[Show more]
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