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Drosophila miR2 primarily targets the 7 GpppN cap structure for translational repression

Zdanowicz, Agnieszka; Thermann, Rolf; Kowalska, Joanna; Jemielity, Jacek; Duncan, Kent; Preiss, Thomas; Darzynkiewicz, Edward; Hentze, Matthias


Understanding the molecular mechanism(s) of how miRNAs repress mRNA translation is a fundamental challenge in RNA biology. Here we use a validated cell-free system from Drosophila embryos to investigate how miR2 inhibits translation initiation. By screening a library of chemical m7GpppN cap structure analogs, we identified defined modifications of the triphosphate backbone that augment miRNA-mediated inhibition of translation initiation but are "neutral" toward general cap-dependent...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Molecular Cell
DOI: 10.1016/j.molcel.2009.09.009


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