Fixing DNA breaks during class switch recombination
Date
2008
Authors
Jolly, Christopher J
Cook, Adam
Manis, John P
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Publisher
Rockefeller University Press
Abstract
Immunoglobulin (Ig) class switch recombination (CSR) involves the breakage and subsequent repair of two DNA sequences, known as switch (S) regions, which flank IgH constant region exons. The resolution of CSR-associated breaks is thought to require the nonhomologous end-joining (NHEJ) DNA repair pathway, but the role of the NHEJ factor DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in this process has been unclear. A new study, in which broken IgH-containing chromosomes in switching B cells were visualized directly, clearly demonstrated that DNA-PKcs and, unexpectedly, the nuclease Artemis are involved in the resolution of switch breaks. JEM
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Keywords
Keywords: DNA dependent protein kinase; double stranded DNA; immunoglobulin heavy chain; nuclease; protein; protein artemis; protein subunit; unclassified drug; B lymphocyte; catalysis; chromosome; chromosome breakage; DNA flanking region; DNA recombination; DNA re
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Source
Journal of Experimental Medicine
Type
Journal article
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2037-12-31
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