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Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways

Larter, Claire; Yeh, Matthew; Haigh, W Geoffrey; Williams, Jacqueline; Brown, Sandie; Bell-Anderson, Kim S; Lee, Sum P; Farrell, Geoffrey


Background/Aims: We determined the effects of dietary lipid composition on steatohepatitis development with particular attention to the nature of lipid molecules that accumulate in the liver and pathways of hepatic triglyceride synthesis. Methods: Mice were fed methionine and choline deficient (MCD) diets supplemented with 20% fat as lard (saturated) or olive oil (monounsaturated), for 3 weeks. Results: Irrespective of dietary lipid composition, MCD-fed mice developed steatosis, ballooning...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Hepatology
DOI: 10.1016/j.jhep.2007.12.011


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