Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways
Background/Aims: We determined the effects of dietary lipid composition on steatohepatitis development with particular attention to the nature of lipid molecules that accumulate in the liver and pathways of hepatic triglyceride synthesis. Methods: Mice were fed methionine and choline deficient (MCD) diets supplemented with 20% fat as lard (saturated) or olive oil (monounsaturated), for 3 weeks. Results: Irrespective of dietary lipid composition, MCD-fed mice developed steatosis, ballooning...[Show more]
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|Source:||Journal of Hepatology|
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