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No clear potentiation of antidepressant medication effects by folic acid + vitamin B 12 in a large community sample

Christensen, Helen; Aiken, Alexandra; Batterham, Philip; Walker, Janine; Mackinnon, Andrew; Fenech, Michael; Hickie, Ian B


Background: Observational studies link low folate levels to depressive symptoms and to poor antidepressant medication response. Evidence supports a role for folate in potentiating the effect of antidepressant medications. Aim: This prospective study examines the effects of folic acid + vitamin B12 supplementation and antidepressant medication in a community-based study of older adults with depressive symptoms. Method: A randomised controlled trial investigated the effectiveness of a medicinal...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Affective Disorders
DOI: 10.1016/j.jad.2010.07.029


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