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No clear potentiation of antidepressant medication effects by folic acid + vitamin B 12 in a large community sample

Christensen, Helen; Aiken, Alexandra; Batterham, Philip; Walker, Janine; Mackinnon, Andrew; Fenech, Michael; Hickie, Ian B

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Background: Observational studies link low folate levels to depressive symptoms and to poor antidepressant medication response. Evidence supports a role for folate in potentiating the effect of antidepressant medications. Aim: This prospective study examines the effects of folic acid + vitamin B12 supplementation and antidepressant medication in a community-based study of older adults with depressive symptoms. Method: A randomised controlled trial investigated the effectiveness of a medicinal...[Show more]

dc.contributor.authorChristensen, Helen
dc.contributor.authorAiken, Alexandra
dc.contributor.authorBatterham, Philip
dc.contributor.authorWalker, Janine
dc.contributor.authorMackinnon, Andrew
dc.contributor.authorFenech, Michael
dc.contributor.authorHickie, Ian B
dc.date.accessioned2015-12-10T22:14:49Z
dc.date.available2015-12-10T22:14:49Z
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/1885/50335
dc.description.abstractBackground: Observational studies link low folate levels to depressive symptoms and to poor antidepressant medication response. Evidence supports a role for folate in potentiating the effect of antidepressant medications. Aim: This prospective study examines the effects of folic acid + vitamin B12 supplementation and antidepressant medication in a community-based study of older adults with depressive symptoms. Method: A randomised controlled trial investigated the effectiveness of a medicinal and two behavioural preventive interventions over a two year period. The medicinal intervention compared dietary supplementation of 400 mcg/d folic acid + 100 mcg/d vitamin B12 to placebo. Self reported use of antidepressant medication over two years was recorded. Participants were screened for psychological distress using the Kessler Distress 10-Scale (K-10; > 15 eligible) and the main outcome measure was change in depressive symptoms on the Patient Health Questionnaire-9 (PHQ-9) at six weeks, six, 12 and 24 months. Nine hundred adults aged 60-74 years were included in the analysis, of whom 209 (23.2%) reported antidepressant use during the follow-up period. Results: A mixed model repeated measures analysis of variance for reduction in depressive symptoms found no significant three-way interaction between supplement group and antidepressant use over time on the PHQ-9 [F4, 825.1 = 0.32, p = 0.87]. A small interaction between supplement group and antidepressant use over time was found for K-10 scores (F4, 799.5 = 2.50, p = 0.0414). Conclusions: There was little evidence for the potentiation of antidepressant medication by folic acid + B12 supplementation on depressive symptomatology. Further research should examine whether effects might be found at higher folic acid dosages or among clinical populations.
dc.publisherElsevier
dc.sourceJournal of Affective Disorders
dc.subjectKeywords: antidepressant agent; cyanocobalamin; folic acid; homocysteine; placebo; adult; aged; article; controlled study; demography; depression; diet supplementation; drug effect; drug potentiation; female; follow up; human; Kessler Distress 10 Scale; major clini Ageing; Antidepressant; Depression; Folate; Folic acid
dc.titleNo clear potentiation of antidepressant medication effects by folic acid + vitamin B 12 in a large community sample
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume130
dc.date.issued2011
local.identifier.absfor111714 - Mental Health
local.identifier.ariespublicationf2965xPUB202
local.type.statusPublished Version
local.contributor.affiliationChristensen, Helen, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAiken, Alexandra, University of Sydney
local.contributor.affiliationBatterham, Philip, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWalker, Janine, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMackinnon, Andrew, University of Melbourne
local.contributor.affiliationFenech, Michael, CSIRO Human Nutrition
local.contributor.affiliationHickie, Ian B, University of Sydney
local.bibliographicCitation.issue1-2
local.bibliographicCitation.startpage37
local.bibliographicCitation.lastpage45
local.identifier.doi10.1016/j.jad.2010.07.029
local.identifier.absseo920209 - Mental Health Services
local.identifier.absseo920410 - Mental Health
local.identifier.absseo920411 - Nutrition
dc.date.updated2016-02-24T08:21:12Z
local.identifier.scopusID2-s2.0-79953181959
local.identifier.thomsonID000290241600006
CollectionsANU Research Publications

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