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The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells

Casaschi, A; Maiyoh, G K; Rubio, B K; Li, Rachel; Adeli, K; Theriault, A G


The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) synthesis and secretion, using HepG2 cells as the model system. The data indicated that XN decreased apoB secretion in a dose-dependent manner under both basal and lipid-rich conditions (as much as 43% at 15 μmol/L). This decrease was associated with increased cellular apoB degradation. To determine the mechanism underlying this effect, we examined triglyceride...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Nutrition


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