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Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza1

Alleva, Lisa; Budd, Alison; Clark, Ian A


Hypercytokinemia is gaining recognition as the mechanism of fatality from influenza. No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g., sepsis and malaria) levels of circulating HMGB1 are elevated and may correlate with death. Using a commercially available ELISA for HMGB1, we found that HMGB1 was not increased in the plasma of influenza virus-infected mice (A/Japan/...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Immunology


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