Skip navigation
Skip navigation

Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza1

Alleva, Lisa; Budd, Alison; Clark, Ian A


Hypercytokinemia is gaining recognition as the mechanism of fatality from influenza. No work to date has addressed the role of high mobility group box 1 protein (HMGB1) in influenza, the parallel being that in other severe proinflammatory cytokine syndromes (e.g., sepsis and malaria) levels of circulating HMGB1 are elevated and may correlate with death. Using a commercially available ELISA for HMGB1, we found that HMGB1 was not increased in the plasma of influenza virus-infected mice (A/Japan/...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Immunology


File Description SizeFormat Image
01_Alleva_Systemic_Release_of_High_2008.pdf440.91 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator