Cytotoxic T cells are the predominant players providing cross-protective immunity induced by {gamma}-irradiated influenza A viruses
Date
2010
Authors
Furuya, Yoichi
Chan, Jennifer
Regner, Matthias
Lobigs, Mario
Koskinen, Aulikki
Kok, Tuckweng
Manavis, Jim
Li, Peng
Mullbacher, Arno
Alsharifi, Mohammed
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Volume Title
Publisher
American Society for Microbiology
Abstract
We previously demonstrated that a single dose of nonadjuvanted intranasal γ-irradiated influenza A virus can provide robust protection in mice against both homologous and heterosubtypic challenges, including challenge with an H5N1 avian virus strain. We
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Keywords
Keywords: perforin; adaptive immunity; adoptive transfer; animal cell; animal cell culture; animal experiment; article; Bagg albino mouse; CD4+ T lymphocyte; CD8+ T lymphocyte; controlled study; cytotoxic T lymphocyte; gamma irradiation; Influenza virus A; Influenz
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Source
Journal of Virology
Type
Journal article
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Restricted until
2037-12-31
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