Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
Hubert, Francois-Xavier; Kinkel, Sarah A; Davey, Gayle M; Phipson, Belinda; Mueller, Scott N; Liston, Adrian; Proietto, Anna; Cannon, Ping Z; Forehan, Simon; Smyth, Gordon K.; Wu, Li; Goodnow, Christopher; Carbone, Francis; Scott, Hamish S.; Heath, William R
To investigate the role of Aire in thymic selection, we examined the cellular requirements for generation of ovalbumin (OVA)-specific CD4 and CD8 T cells in mice expressing OVAunder the control of the rat insulin promoter. Aire deficiency reduced the number of mature single-positive OVA-specific CD4+ or CD8+T cells in the thymus, independent of OVA expression. Importantly, it also contributed in 2 ways to OVA-dependent negative selection depending on the T-cell type. Aire-dependent negative...[Show more]
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