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Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity

Ramshaw, Ian; Ranasinghe, Charani

Description

All HIV-1 'systemic vaccine trials'-in humans have yielded poor outcomes. Thus, it is important to understand whether the route of delivery influences the quality of protective CTL immunity. Using heterologous poxvirus immunisation we have shown that systemically (i.m./ i.m.) immunised CD8+ T cells generated higher levels of IL-4/ IL-13 compared to mucosal delivery and expression also correlated with i.m./i.m. immunised mice eliciting CTL of lower avidity. Studies using IL-4-/- and IL-13-/- KO...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/38061
Source: European Journal of Immunology
DOI: 10.1002/eji.200838995

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