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Diversity in CD8 + T cell differentiation

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Parish, Ian; Kaech, Susan

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CD8+ T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8+ T cells make to antigenic stimulation with a focus on how CD8+ T cell responses are regulated to achieve different immune outcomes. In particular, we discuss phenotypic diversity during tolerance induction as well as signals that drive...[Show more]

dc.contributor.authorParish, Ian
dc.contributor.authorKaech, Susan
dc.date.accessioned2015-12-08T22:43:31Z
dc.identifier.issn0952-7915
dc.identifier.urihttp://hdl.handle.net/1885/37321
dc.description.abstractCD8+ T cells are key effector cells of the adaptive immune system, however their activity must be tightly regulated to allow pathogen clearance whilst preventing immunopathology and autoimmunity. In this review, we summarise the diversity of responses that CD8+ T cells make to antigenic stimulation with a focus on how CD8+ T cell responses are regulated to achieve different immune outcomes. In particular, we discuss phenotypic diversity during tolerance induction as well as signals that drive effector and memory cell differentiation in response to infection.
dc.publisherElsevier
dc.sourceCurrent Opinion in Immunology
dc.subjectKeywords: adaptive immunity; autoimmunity; CD8+ T lymphocyte; cell activity; cellular immunity; effector cell; immunological tolerance; immunopathology; immunostimulation; lymphocyte differentiation; memory T lymphocyte; phenotype; review; signal transduction; Anim
dc.titleDiversity in CD8 + T cell differentiation
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume21
dc.date.issued2009
local.identifier.absfor110703 - Autoimmunity
local.identifier.ariespublicationu6800332xPUB147
local.type.statusPublished Version
local.contributor.affiliationParish, Ian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKaech, Susan, Yale University School of Medicine
local.description.embargo2037-12-31
local.bibliographicCitation.issue3
local.bibliographicCitation.startpage291
local.bibliographicCitation.lastpage297
local.identifier.doi10.1016/j.coi.2009.05.008
dc.date.updated2016-02-24T11:37:56Z
local.identifier.scopusID2-s2.0-67049136157
local.identifier.thomsonID000267960800009
CollectionsANU Research Publications

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