Selection Pressure-Driven Evolution of the Epstein-Barr Virus-Encoded Oncogene LMP1 in Virus Isolates from Southeast Asia

Burrows, Jacqueline M.; Bromham, Lindell; Woolfit, Megan; Piganeau, Gwenaël; Tellam, Judy; Connolly, Geoff; Webb, Natasha; Poulsen, Leith; Cooper, Leanne; Burrows, Scott; Moss, Denis J; Haryana, Sofia M.; Ng, Mun; Nicholls, John M.; Khanna, Rajiv

Selection Pressure-Driven Evolution of the Epstein-Barr Virus-Encoded Oncogene LMP1 in Virus Isolates from Southeast Asia

Date

2004

Authors

Burrows, Jacqueline M.

Bromham, Lindell

Woolfit, Megan

Piganeau, Gwenaël

Tellam, Judy

Connolly, Geoff

Webb, Natasha

Poulsen, Leith

Cooper, Leanne

Burrows, Scott

Publisher

American Society for Microbiology

Abstract

The geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have been