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Coenzyme A biosynthesis: an antimicrobial drug target

Spry, Christina; Kirk, Kiaran; Saliba, Kevin


Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic microorganisms. Since the structure of pantothenic acid was determined, many analogues of this essential metabolite have been prepared. Several have been demonstrated to exert an antimicrobial effect against a range of microorganisms by inhibiting the utilization of pantothenic acid, validating pantothenic acid utilization as a potential novel antimicrobial drug target. This review commences with an...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: FEMS Microbiology Reviews
DOI: 10.1111/j.1574-6976.2007.00093.x


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