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Interleukin-15 mediates potent antiviral responses via an Interferon-dependent mechanism

Foong, Yvonne; Jans, David A; Rolph, Michael S; Gahan, M E; Mahalingam, Surendran


Interleukin-15 (IL-15) is a potent growth factor for activated T and natural killer (NK) cells, stimulator of memory T cells and plays an important role in viral immunity. To investigate mechanisms underlying the antiviral activity of IL-15, a recombinant vaccinia virus (rVV) encoding murine IL-15 (VV-IL-15) was constructed. Following infection of mice with VV-IL-15, virus titres in the ovaries were significantly reduced compared to mice infected with control VV. Growth of VV-IL-15 was also...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2009.07.030


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