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A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

Chu, Jessie; Hong, Nancy A; Masuda, Claudio A.; Jenkins, Brian V.; Nelms, Keats; Goodnow, Christopher; Glynne, Richard; Wu, Hua; Masliah, Eliezer; Joazeiro, Claudio A.P.; Kay, Steve A.

Description

A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/33945
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0812819106

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