Skip navigation
Skip navigation

Memory CD8+ T Cell Responses Expand When Antigen Presentation Overcomed T Cell Self-Regulation

Cockburn, Ian; Chakravarty, Sumana; Overstreet, Michael G; Garcia-Sastre, Adolfo; Zavala, Fidel

Description

Antimicrobial memory CD8+ T cell responses are not readily expanded by either repeated infections or immunizations. This is a major obstacle to the development of T cell vaccines. Prime-boost immunization with heterologous microbes sharing the same CD8+ epitope can induce a large expansion of the CD8+ response; however, different vectors vary greatly in their ability to boost for reasons that are poorly understood. To investigate how efficient memory T cell expansion can occur, we evaluated...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/33779
Source: Journal of Immunology
DOI: 10.4049/jimmunol.180.1.64

Download

File Description SizeFormat Image
01_Cockburn_Memory_CD8+_T_Cell_Responses_2008.pdf1.13 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator