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Pro-oxidant-mediated hepatic fibrosis and effects of antioxidant intervention in murine dietary steatohepatitis

Phung, Nghi; Pera, Natasha; Farrell, Geoffrey; Leclercq, Isabelle; Hou, Jung Yun; George, Jacob


The mechanistic significance of oxidative stress to fibrogenesis in the methionine and choline-deficient (MCD) diet-induced model of steatohepatitis was evaluated by antioxidant intervention, using either vitamin E or L-2-oxothiazolidine-4-carboxylate (OTC), a cysteine precursor that promotes glutathione synthesis. Significant depletion of hepatic reduced glutathione (GSH) and elevation of thio-barbituric acid reactive substances (TBARS) occurred from week 3 in association with hepatic injury...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Journal of Molecular Medicine
DOI: 10.3892/ijmm_00000220


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