Linterman, Michelle; Rigby, Robert; Wong, Raphael; Yu, Di; Brink, Robert; Cannons, Jennifer L.; Schwartzberg, Pamela L; Cook, Matthew; Walters, Giles; Garcia De Vinuesa, Maria Carola
Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (TFH) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san allele of Roquin, which encodes a RING-type ubiquitin ligase, develop GCs in the absence...[Show more]
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