Follicular helper T cells are required for systemic autoimmunity
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Linterman, Michelle; Rigby, Robert; Wong, Raphael; Yu, Di; Brink, Robert; Cannons, Jennifer L.; Schwartzberg, Pamela L; Cook, Matthew; Walters, Giles; Garcia De Vinuesa, Maria Carola
Description
Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (TFH) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san allele of Roquin, which encodes a RING-type ubiquitin ligase, develop GCs in the absence...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/32591 |
Source: | Journal of Experimental Medicine |
DOI: | 10.1084/jem.20081886 |
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01_Linterman_Follicular_helper_T_cells_are_2009.pdf | 9.39 MB | Adobe PDF | Request a copy |
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