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Heterogeneity in function of small artery smooth muscle BKCa: involvement of the β1-subunit

Yang, Yan; Murphy , Tim V; Ella, Srikanth R.; Grayson , T Hilton; Haddock, Rebecca; Hwang, Yun T; Braun, Andrew P; Peichun, Gui; Korthuis, Ronald J; Davis, Michael J; Hill, Michael A


Arteriolar myogenic vasoconstriction occurs when increased stretch or membrane tension leads to smooth muscle cell depolarization and opening of voltage-gated Ca2+ channels. To prevent positive feedback and excessive pressure-induced vasoconstriction, studies in cerebral artery smooth muscle have suggested that activation of large conductance, Ca2+-activated K+ channels (BKCa) provides an opposing hyperpolarizing influence reducing Ca2+ channel activity. We have hypothesized that this mechanism...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2009.169920


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