Sympathetic overdrive in obesity involves purinergic hyperactivity in the resistance vasculature
While a close correlation exists in obese humans between sympathetic, adrenergic hyperactivity and structural and functional organ damage, a role for the co-transmitter, ATP, in vascular function remains unexplored. We therefore studied sympathetic nerve-mediated responses of pressurised small mesenteric arteries from control and obese rats. Diet-induced obesity significantly increased the amplitude of vasoconstriction to transmural nerve stimulation (1-10 Hz; P < 0.05). At 1 and 5 Hz, both...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Physiology|
|01_Haddock_Sympathetic_overdrive_in_2011.pdf||1.21 MB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.