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Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs

Pardo, Julian; Wallich, R; Martin, P; Urban, C; Rongvaux, A; Flavell, R.A.; Mullbacher, Arno; Borner, C; Simon, Markus M


Granzyme B (gzmB) of cytotoxic T lymphocytes (CTL) is essential for recovery from intracellular pathogens, but the molecular basis of its action is still unresolved. Here, we analyzed gzmB-mediated death pathways under physiological conditions using ex vivo virus-immune CTLs that express perf and gzmB, but not gzmA (gzmB+CTL). We show that gzmB+CTL abrogate target cell proliferation most likely by inducing cell death, independent of caspases and mitochondrial signaling. In addition, the data...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Cell Death and Differentiation
DOI: 10.1038/sj.cdd.4402289


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