Allergy and Risk of Childhood Leukaemia: Results from the UKCCS
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Hughes, Ann Maree; Lightfoot, Tracy; Simpson, Jill; Ansell, Pat; McKinney, Patricia A; Kinsey, Sally E; Mitchell, Christopher D; Eden, Tim O B; Greaves, Mel; Roman, Eve
Description
We investigated the relationship between childhood leukaemia and preceding history of allergy. A nationwide case-control study of childhood cancers was conducted in the United Kingdom with population-based sampling of cases (n = 839) and controls (n = 1,337), matched on age, sex and region of residence. Information about clinically diagnosed allergies was obtained from primary care records. More than a third of subjects had at least one allergy diagnosed prior to leukaemia diagnosis (cases) or...[Show more]
dc.contributor.author | Hughes, Ann Maree | |
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dc.contributor.author | Lightfoot, Tracy | |
dc.contributor.author | Simpson, Jill | |
dc.contributor.author | Ansell, Pat | |
dc.contributor.author | McKinney, Patricia A | |
dc.contributor.author | Kinsey, Sally E | |
dc.contributor.author | Mitchell, Christopher D | |
dc.contributor.author | Eden, Tim O B | |
dc.contributor.author | Greaves, Mel | |
dc.contributor.author | Roman, Eve | |
dc.date.accessioned | 2015-12-08T22:09:25Z | |
dc.identifier.issn | 0020-7136 | |
dc.identifier.uri | http://hdl.handle.net/1885/29019 | |
dc.description.abstract | We investigated the relationship between childhood leukaemia and preceding history of allergy. A nationwide case-control study of childhood cancers was conducted in the United Kingdom with population-based sampling of cases (n = 839) and controls (n = 1,337), matched on age, sex and region of residence. Information about clinically diagnosed allergies was obtained from primary care records. More than a third of subjects had at least one allergy diagnosed prior to leukaemia diagnosis (cases) or pseudo-diagnosis (controls). For both total acute lymphoblastic leukaemia (ALL) and common-ALL/precursor B-cell ALL (c-ALL), a history of eczema was associated with a 30% significant reduction in risk: the odds ratios (OR) and 95% confidence intervals (CI) were 0.70 (0.51-0.97) and 0.68 (0.48-0.98), respectively. Similar associations were observed for hayfever (OR = 0.47; 95% CI: 0.26-0.85 and OR = 0.62; 95% CI: 0.33-1.16 for ALL and c-ALL, respectively). No such patterns were seen either for asthma and ALL, or for any allergy and acute myeloid leukaemia. A comparative analysis of primary care records with parents recall of allergy revealed only moderate agreement with contemporaneous clinical diagnoses for both cases and controls - confirming the unreliability of parental report at interview. Our finding of a reciprocal relationship between allergy and ALL in children is compatible with the hypothesis that a dysregulated immune response is a critical determinant of childhood ALL. | |
dc.publisher | John Wiley & Sons Inc | |
dc.source | International Journal of Cancer | |
dc.subject | Keywords: acute lymphoblastic leukemia; age distribution; allergy; article; B cell leukemia; cancer risk; case control study; child; childhood cancer; controlled study; female; hay fever; human; immune response; interview; leukemia; major clinical study; male; prim Acute; Allergy; Case-control; Child; Leukaemia; Lymphoblastic | |
dc.title | Allergy and Risk of Childhood Leukaemia: Results from the UKCCS | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 121 | |
dc.date.issued | 2007 | |
local.identifier.absfor | 111202 - Cancer Diagnosis | |
local.identifier.ariespublication | u4133361xPUB62 | |
local.type.status | Published Version | |
local.contributor.affiliation | Hughes, Ann Maree, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Lightfoot, Tracy, University of York | |
local.contributor.affiliation | Simpson, Jill, University of York | |
local.contributor.affiliation | Ansell, Pat, University of York | |
local.contributor.affiliation | McKinney, Patricia A, University of Leeds | |
local.contributor.affiliation | Kinsey, Sally E, St James University Hospital | |
local.contributor.affiliation | Mitchell, Christopher D, University of Oxford | |
local.contributor.affiliation | Eden, Tim O B, Christie Hospital NHS Trust | |
local.contributor.affiliation | Greaves, Mel, Institute of Cancer Research, Chester Beatty Laboratories | |
local.contributor.affiliation | Roman, Eve, University of York | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 4 | |
local.bibliographicCitation.startpage | 819 | |
local.bibliographicCitation.lastpage | 824 | |
local.identifier.doi | 10.1002/ijc.22702 | |
dc.date.updated | 2015-12-08T07:24:54Z | |
local.identifier.scopusID | 2-s2.0-34547107057 | |
Collections | ANU Research Publications |
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