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Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses

Chen, Weiqiang; Foo, Suan-Sin; Li, Rachel W; Smith, Paul N; Mahalingam, Suresh


BACKGROUND Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya virus (CHIKV) have caused widespread outbreaks of chronic polyarthritis. The inflammatory responses in alphavirus-induced arthritis and osteoarthritis (OA) share many similar features, which suggests the possibility of exacerbated alphavirus-induced bone pathology in individuals with pre-existing OA. Here, we investigated the susceptibility of osteoblasts (OBs) from OA patients to RRV infection and dissected...[Show more]

CollectionsANU Research Publications
Date published: 2014-11-19
Type: Journal article
Source: Virology Journal
DOI: 10.1186/s12985-014-0189-9


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