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Gene editing of the multi-copy H2A.B gene and its importance for fertility 06 Biological Sciences 0604 Genetics Jin-Soo Kim

Anuar, Nur Diana; Kurscheid, Sebastian; Field, Matthew; Zhang, Lei; Rebar, Edward; Gregory, Philip; Buchou, Thierry; Bowles, Josephine; Koopman, Peter; Tremethick, David; Soboleva, Tatiana A

Description

Altering the biochemical makeup of chromatin by the incorporation of histone variants during development represents a key mechanism in regulating gene expression. The histone variant H2A.B, H2A.B.3 in mice, appeared late in evolution and is most highly expressed in the testis. In the mouse, it is encoded by three different genes. H2A.B expression is spatially and temporally regulated during spermatogenesis being most highly expressed in the haploid round spermatid stage. Active genes gain H2A.B...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/281468
Source: Genome Biology
DOI: 10.1186/s13059-019-1633-3
Access Rights: Open Access

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