Regulatory T cells suppress CD8 + T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities
Date
2005
Authors
Haeryfar, S M Mansour
DiPaolo, R J
Tscharke, David
Bennink, Jack R
Yewdell, Jonathan W
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American Association of Immunologists
Abstract
Little is known regarding the participation of CD4+CD25 + regulatory T cells (Treg) in TCD8+ responses. In this study, we show that Treg depletion via treatment with anti-CD25 mAb (PC61) significantly enhances TCD8+ responses to influenza A virus, vaccinia virus, and SV40-transformed cells induced by either direct priming or cross-priming. PC61 did not enhance T CD8+ responses in CD4-deficient mice, providing the initial demonstration that PC61 acts on a subset of TCD4+, and not on other cells that express either CD25 or a fortuitously cross-reactive Ag. We further show that Treg selectively suppress responses to the most immunodominant TCD8+ determinants in the three systems examined. Therefore, Treg influence T CD8 immunodominance hierarchies by moderating disparities in responses to different determinants.
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Keywords: CD4 antigen; CD8 antigen; cross reacting antigen; epitope; interleukin 2 receptor alpha; interleukin 2 receptor antibody; monoclonal antibody PC61; unclassified drug; virus large T antigen; adolescent; animal cell; antigen presentation; article; cell tran
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Journal of Immunology
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Journal article
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2037-12-31
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