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Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening

Mini Sasi, Vishnu; Ullrich, Sven; Ton, Jennifer; Fry, Sarah E.; Johansen-Leete, Jason; Payne, Richard J.; Nitsche, Christoph; Jackson, Colin


The main protease (Mpro) of SARS-CoV-2 is essential for viral replication and has been the focus of many drug discovery efforts since the start of the COVID-19 pandemic. Nirmatrelvir (NTV) is an inhibitor of SARS-CoV-2 Mpro that is used in the combination drug Paxlovid for the treatment of mild to moderate COVID-19. However, with increased use of NTV across the globe, there is a possibility that future SARS-CoV-2 lineages will evolve resistance to NTV. Early prediction and monitoring of...[Show more]

CollectionsANU Research Publications
Date published: 2022-11-03
Type: Journal article
Source: Biochemistry
DOI: 10.1021/acs.biochem.2c00489
Access Rights: Open Access


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