CD8+ T Cell Cross-Priming via Transfer of Proteasome Substrates
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Authors
Norbury, Christopher
Basta, Sameh
Donohue, Keri B
Tscharke, David
Princiotta, Michael
Berglund, Peter
Gibbs, James
Bennink, Jack R
Yewdell, Jonathan W
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American Association for the Advancement of Science
Abstract
"Cross-priming" describes the activation of naïve CD8 + T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from "donor" cells. Antigen transfer is believed to be mediated by donor cell-derived molecular chaperones
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2037-12-31