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The neuroactive steroids alphaxalone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons

Gaul, Simon; Ozsarac, Nesrin; Liu, Lu; Fink, Rainer; Gage, Peter

Description

The effects of the neuroactive steroids alphaxalone and pregnanolone on single GABAA receptor channels were tested in cell-attached and inside-out patches from cultured newborn rat hippocampal neurons. The conductance of these single channels ranged between 10 and 80 pS when exposed to low (0.5-3 μM) GABA concentrations. These GABA concentrations activated low-conducting channels (<40 pS) in 78% of the patches, 22% of patches had channels with a maximum conductance above 40 pS. Alphaxalone at...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/27708
Source: Journal of Steroid Biochemistry and Molecular Biology
DOI: 10.1016/j.jsbmb.2006.09.042

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