The neuroactive steroids alphaxalone and pregnanolone increase the conductance of single GABAA channels in newborn rat hippocampal neurons
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Gaul, Simon; Ozsarac, Nesrin; Liu, Lu; Fink, Rainer; Gage, Peter
Description
The effects of the neuroactive steroids alphaxalone and pregnanolone on single GABAA receptor channels were tested in cell-attached and inside-out patches from cultured newborn rat hippocampal neurons. The conductance of these single channels ranged between 10 and 80 pS when exposed to low (0.5-3 μM) GABA concentrations. These GABA concentrations activated low-conducting channels (<40 pS) in 78% of the patches, 22% of patches had channels with a maximum conductance above 40 pS. Alphaxalone at...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/27708 |
Source: | Journal of Steroid Biochemistry and Molecular Biology |
DOI: | 10.1016/j.jsbmb.2006.09.042 |
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01_Gaul_The_neuroactive_steroids_2007.pdf | 665.87 kB | Adobe PDF | Request a copy |
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