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Nox1 upregulates the function of vascular T-type calcium channels following chronic nitric oxide deficit

Howitt, Lauren; Matthaei, Klaus; Hill, Caryl; Drummond, Grant


Cardiovascular disease is characterised by reduced nitric oxide bioavailability resulting from oxidative stress. Our previous studies have shown that nitric oxide deficit per se increases the contribution of T-type calcium channels to vascular tone through increased superoxide from NADPH oxidase (Nox). The aim of the present study was therefore to identify the Nox isoform responsible for modulating T-type channel function, as T-type channels are implicated in several pathophysiological...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Pflugers Archives European Journal of Physiology
DOI: 10.1007/s00424-014-1548-5


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