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Current Status of Schistosomiasis Control and Prospects for Elimination in the Dongting Lake Region of the People's Republic of China

Li, Fei-Yue; Hou, Xun-Ya; Tan, Hong-Zhuan; Williams, Gail; Gray, Darren; Gordon, Catherine A.; Kurscheid, Johanna; Clements, Archie; Li, Yue-Sheng; McManus, Donald P.

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Schistosomiasis japonica is an ancient parasitic disease that has severely impacted human health causing a substantial disease burden not only to the Chinese people but also residents of other countries such as the Philippines, Indonesia and, before the 1970s, Japan. Since the founding of the new People's Republic of China (P. R. China), effective control strategies have been implemented with the result that the prevalence of schistosomiasis japonica has decreased markedly in the past 70 years....[Show more]

dc.contributor.authorLi, Fei-Yue
dc.contributor.authorHou, Xun-Ya
dc.contributor.authorTan, Hong-Zhuan
dc.contributor.authorWilliams, Gail
dc.contributor.authorGray, Darren
dc.contributor.authorGordon, Catherine A.
dc.contributor.authorKurscheid, Johanna
dc.contributor.authorClements, Archie
dc.contributor.authorLi, Yue-Sheng
dc.contributor.authorMcManus, Donald P.
dc.date.accessioned2022-07-27T04:44:39Z
dc.date.available2022-07-27T04:44:39Z
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/1885/269979
dc.description.abstractSchistosomiasis japonica is an ancient parasitic disease that has severely impacted human health causing a substantial disease burden not only to the Chinese people but also residents of other countries such as the Philippines, Indonesia and, before the 1970s, Japan. Since the founding of the new People's Republic of China (P. R. China), effective control strategies have been implemented with the result that the prevalence of schistosomiasis japonica has decreased markedly in the past 70 years. Historically, the Dongting Lake region in Hunan province is recognised as one of the most highly endemic for schistosomiasis in the P.R. China. The area is characterized by vast marshlands outside the lake embankments and, until recently, the presence of large numbers of domestic animals such as bovines, goats and sheep that can act as reservoir hosts for Schistosoma japonicum. Considerable social, economic and environmental changes have expanded the Oncomelania hupensis hupensis intermediate snail host areas in the Dongting lake region increasing the potential for both the emergence of new hot spots for schistosomiasis transmission, and for its re-emergence in areas where infection is currently under control. In this paper, we review the history, the current endemic status of schistosomiasis and the control strategies in operation in the Dongting Lake region. We also explore epidemiological factors contributing to S. japonicum transmission and highlight key research findings from studies undertaken on schistosomiasis mainly in Hunan but also other endemic Chinese provinces over the past 10 years. We also consider the implications of these research findings on current and future approaches that can lead to the sustainable integrated control and final elimination of schistosomiasis from the P. R. China and other countries in the region where this unyielding disease persists.
dc.description.sponsorshipChina Hunan Provincial Science and Technology Department (project No.2017WK2073) and the National Health and Medical Research Council of Australia (ID: APP1160046, APP1037304 and APP1098244). DPM is a NHMRC Senior Principal Research Fellow and Senior Scientist at QIMR Berghofer Medical Research Institute.
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherFrontiers Research Foundation
dc.rightsCopyright © 2020 Li, Hou, Tan, Williams, Gray, Gordon, Kurscheid, Clements, Li and McManus.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceFrontiers in Immunology
dc.titleCurrent Status of Schistosomiasis Control and Prospects for Elimination in the Dongting Lake Region of the People's Republic of China
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume11
dc.date.issued2020
local.identifier.absfor000000 - Internal ANU use only
local.identifier.ariespublicationa383154xPUB14966
local.publisher.urlhttps://www.frontiersin.org/journals/immunology
local.type.statusPublished Version
local.contributor.affiliationLi, Fei-Yue, Central South University
local.contributor.affiliationHou, Xun-Ya, Hunan Institute of Parasitic Diseases
local.contributor.affiliationTan, Hong-Zhuan, Central South University
local.contributor.affiliationWilliams, Gail, University of Queensland
local.contributor.affiliationGray, Darren, College of Health and Medicine, ANU
local.contributor.affiliationGordon, Catherine A., QIMR Berghofer Medical Research Institute
local.contributor.affiliationKurscheid, Johanna, College of Health and Medicine, ANU
local.contributor.affiliationClements , Archie , Curtin University
local.contributor.affiliationLi, Yue-Sheng, Hunan Institute of Parasitic Diseases
local.contributor.affiliationMcManus, Donald P., QIMR Berghofer Medical Research Institute
dc.relationhttp://purl.org/au-research/grants/nhmrc/GNT1160046
dc.relationhttp://purl.org/au-research/grants/nhmrc/1037304
dc.relationhttp://purl.org/au-research/grants/nhmrc/1098244
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage9
local.identifier.doi10.3389/fimmu.2020.574136
dc.date.updated2021-08-01T08:24:08Z
dcterms.accessRightsOpen Access
dc.provenanceThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.licenseCreative Commons Attribution License (CC BY)
CollectionsANU Research Publications

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